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Objective:To analyze the changes of carotid artery ultrasound in diabetes mellitus patients complicated with cerebral infarction.Methods:From March 2017 to June 2018, 55 type 2 diabetes patients complicated with cerebral infarction in the Second People's Hospital of Yuhang District were selected as study group.Another 50 diabetes patients without cerebral infarction were selected as simple group, and 60 healthy people were selected as control group.The carotid artery colour doppler check was implemented, the carotid artery ultrasound media thickness(IMT) index and carotid plaques were compared in three groups.Results:The IMT index in the study group was (1.84±0.23), which was significantly higher than (1.32±0.21) in the control group ( t=12.674, P<0.05). The IMT index of the simple group was (1.59±0.19), which was significantly lower than that of the study group ( t=6.037, P<0.05). Compared with the control group, the IMT index of the simple group was significantly higher ( t=7.009, P<0.05). The detective rate of carotid unstable plaque in the study group was 85.37%(35/41), which was significantly higher than 11.54%(3/26) in the control group (χ 2 =21.371, P<0.05). The detective rate of carotid unstable plaque in the simple group was 45.95%(17/37), which was significantly lower than that in the study group (χ 2=19.118, P<0.05). The detective rate of carotid unstable plaque between the control group and the simple group had statistically significant difference (χ 2=18.342, P<0.05). Conclusion:The IMT index of carotid artery in diabetes patients complicated with cerebral infarction is high, and the unstable plaque examination rate is high, which are the risk factors for cerebral infarction in patients with diabetes.To do a good job in carotid atherosclerosis for diabetic patients, and give active treatment, can prevent cerebral infarction.
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Objective@#To analyze the changes of carotid artery ultrasound in diabetes mellitus patients complicated with cerebral infarction.@*Methods@#From March 2017 to June 2018, 55 type 2 diabetes patients complicated with cerebral infarction in the Second People's Hospital of Yuhang District were selected as study group.Another 50 diabetes patients without cerebral infarction were selected as simple group, and 60 healthy people were selected as control group.The carotid artery colour doppler check was implemented, the carotid artery ultrasound media thickness(IMT) index and carotid plaques were compared in three groups.@*Results@#The IMT index in the study group was (1.84±0.23), which was significantly higher than (1.32±0.21) in the control group (t=12.674, P<0.05). The IMT index of the simple group was (1.59±0.19), which was significantly lower than that of the study group (t=6.037, P<0.05). Compared with the control group, the IMT index of the simple group was significantly higher (t=7.009, P<0.05). The detective rate of carotid unstable plaque in the study group was 85.37%(35/41), which was significantly higher than 11.54%(3/26) in the control group (χ2 =21.371, P<0.05). The detective rate of carotid unstable plaque in the simple group was 45.95%(17/37), which was significantly lower than that in the study group (χ2=19.118, P<0.05). The detective rate of carotid unstable plaque between the control group and the simple group had statistically significant difference (χ2=18.342, P<0.05).@*Conclusion@#The IMT index of carotid artery in diabetes patients complicated with cerebral infarction is high, and the unstable plaque examination rate is high, which are the risk factors for cerebral infarction in patients with diabetes.To do a good job in carotid atherosclerosis for diabetic patients, and give active treatment, can prevent cerebral infarction.
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Objective To compare the clinical value of uterine submucosal myoma classification by two dimensional and three-dimensional contrast-enhanced ultrasonography and surgical pathologic results.Methods The imaging data of ultrasonographic hysterography including 2D and 3D of 124 patients with uterine submucosal myoma were retrospectively analyzed,and the results were compared with the surgical pathologic results.The diagnostic accuracy of uterine submucosal myoma classification and the operation success rate of uterine submucosal myoma for Ⅰ grade by ultrasonographic hysterography including 2D and 3D were compared.Results The patients were diagnosed pathologically with 0,Ⅰ and Ⅱ grade of uterine submucosal myoma in 26 cases,52 cases,68 cases,respectively.The patients were diagnosed by 2D ultrasonic sonohysterography with 0 grade,Ⅰ grade and Ⅱ grade of uterine submucosal myoma in 26 cases,62 cases,58 cases,respectively.The patients were diagnosed by 3D ultrasonic sonohysterography with 0,Ⅰ and Ⅱ grade of uterine submucous myoma in 26 cases,52 cases,68 cases,respectively.For pathological results as thegold standard,the diagnostic sensitivity,specificity and accuracy of uterine submucosal myoma for 0 grade by 2D and 3D ultrasonic sonohysterography were all 100.00％.The diagnostic sensitivity,specificity and accuracy of uterine submucosal myoma for Ⅰ and Ⅱ grade by 2D ultrasonic sonohysterography were 92.32％,79.46％,85.00％,respectively.The diagnostic sensitivity,specificity and accuracy of uterine submucosal myoma for Ⅰ and Ⅱ grade by 3D ultrasonic sonohysterography were 96.24％,88.24％,91.76％,respectively.There were significant differences in the diagnostic sensitivity,specificity and accuracy of submucosal myoma of uterus for Ⅰ and Ⅱ grade by 2 D and 3 D ultrasonic sonohysterography (x2 =3.21,2.78,2.17,2.33,all P ＜ 0.05).The patients diagnosed as uterine submucous myoma for 0 grade all underwent the hysteroscopic surgery for successful resection,while the patients with uterine submucous myoma for Ⅱ grade underwent laparoscopic surgery or open surgery.The operation success rates of uterine submucous myoma for Ⅰ grade by hysteroscopic surgery diagnosed by 2D and 3D ultrasonic sonohysterography were 75.81％,98.07％,respectively.The operation success rate of uterine submucous myoma for Ⅰ grade by hysteroscopic surgery diagnosed by 3D ultrasonic sonohysterography was significantly higher than that diagnosed by 2D ultrasonic sonohysterography (x2 =7.15,P ＜ 0.05).Conclusion The accuracy of uterine submucosal myoma classification by 3D ultrasonographic hysterography is better than 2D ultrasonographic hysterography.
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Objective To evaluate the relationship between neuropeptide S (NPS) in the amygdala and 5-hydroxytryptamine (5-HT) and GABA in spinal dorsal horns of rats with neuropathic pain.Methods Eighty pathogen-free healthy male Sprague-Dawley rats,weighing 200-260 g,aged 2 months,were divided into 4 groups (n =20 each) using a random number table:sham operation group (group Sham),neuropathic pain group (group NP),low dose NPS group (group L-NPS) and high dose NPS group (group H-NPS).The neuropathic pain model was established by left L5,6 spinal nerve ligation (SNL) in anesthetized rats.NPS was injected into the bilateral amygdala at 3,6,9,12,15 and 18 days after SNL in LNPS group (10 pmol per side) and H-NPS group (100 pmol per side).The mechanical paw withdrawal threshold (MWT) and thermal paw withdrawal latency (TWL) were measured at 2 days before SNL and 1,4,7,11,14,17 and 21 days after SNL.Five rats were selected at 7,14 and 21 days after SNL and sacrificed,and the lumbar segment (L5) of the spinal cord was removed for detection of the expression of 5-HT and GABA in spinal dorsal horns by immunofluorescence histochemistry.Results Compared with group Sham,the MWT was significantly decreased,the TWL was shortened,and the expression of 5-HT and GABA in spinal dorsal horns was down-regulated in NP,L-NPS and H-NPS groups (P＜0.05).Compared with group NP,the MWT was significantly increased,the TWL was prolonged,and the expression of 5-HT and GABA in spinal dorsal horns was up-regulated in L-NPS and H-NPS groups (P＜0.05).Compared with group L-NPS,the MWT was significantly increased,the TWL was prolonged,and the expression of 5-HT and GABA in spinal dorsal horns was up-regulated in group H-NPS (P＜0.05).Conclusion The spinal mechanism of endogenous analgesia induced by NPS in the amygdala may be related to up-regulation of the expression of 5-HT and GABA in spinal dorsal horns of rats with neuropathic pain.